We strive to maintain our health and improve the quality of life. Of course, some criteria are needed to determine and objectively evaluate it. If we talk about the potential of women’s health, then this criterion is the ovarian reserve . “It is this that determines how long we will be young, whether we will be able to have children, what kind of vitality we have in general.” – say women. Why?
Factors Affecting Ovarian Reserve
It used to be thought that age was the only factor that determined ovarian potential. But recently the situation has changed. Increasingly, women in their thirties are showing poor ovarian reserve—essentially early ovarian aging.
The ovarian reserve determines the quantity and quality of the ovarian primary follicular pool . Poor ovarian reserve indicates a decrease in the number of the ovarian follicular pool and a decrease in their functional state (i.e., the inability to healthy maturation of the follicle with a full-fledged egg) in women of reproductive age, which is an important cause of infertility in many couples.
Ovarian reserve is mostly genetically determined, but there are many factors such as smoking, stress, abortion, illness, long-term use of OCs, autoimmune reactions (they find antibodies in the blood against ovarian tissues), poor nutrition, changing partners, chemotherapy, any ovarian surgery that deplete this supply.
Premature ovarian failure
A condition in which the reproductive potential of the ovaries is sharply reduced is called premature ovarian failure syndrome , the key indicator of which is the depletion of the ovarian reserve .
Characteristic features include the following
- The menstrual cycle becomes shorter – instead of your usual 28 days, the cycle comes in 25/26 days, i.e. the luteal phase is 10 days (luteal phase deficiency of the cycle (NLF)).
- Menstruation becomes more abundant at the beginning, and then quickly becomes scarce, their duration decreases to 2-3 days
- Ovulatory cycles are replaced by anovulatory cycles, as a result, progesterone decreases.
- Low blood estrogen levels, elevated follicle-stimulating hormone (FSH) > 15 mU/l
- Low levels of inhibin B and dehydroepiandrosterone sulfate (DHEA-S)
- Increased thyroid-stimulating hormone (TSH) in 25% of cases with autoimmune thyroid processes
- Number of antral follicles detected on ultrasound < 5
- Low Anti-Müllerian Hormone (AMH) test < 1.1 ng/mL
Some women suffering from premature ovarian failure have had periodic ovulation and pregnancies. To identify these patients, the determination of indicators of ovarian reserve play a leading role.
The main marker for determining ovarian reserve is AMH
Anti-Müllerian Hormone (AMH) ensures the development of the reproductive organs and fertility. Named after the 19th century German physician and biologist Johann Müller.
AMH is synthesized in the ovaries in women and in the testicles in men. Its production occurs independently of the work of the pituitary gland and hypothalamus. Therefore, you can donate blood for research at any phase of the cycle. The level of AMH depends only on the state of the gonads (gonads), the resource of which is laid at the time of conception in the form of primary follicles (primordial). Their number can range from a few hundred to 5 million. It depends not only on the age and health of the parents, but also on their love and passion.
Female anti-Müllerian hormone is produced in the primary ovarian follicles. If there are few of them, then its level will be low, and if there are many, then it will be higher.
The AMH norm ranges from 1 to 2.5 ng/ml (reference values may vary in different laboratories). It reaches its maximum limit at 20-30 years of age – the active reproductive age. A sharp decline begins when the primordial pool is reduced to 25 thousand follicles, normally this corresponds to the age of 37.5 years.
Studies show that an AMH level of < 0.086 ng/mL clearly corresponds to the onset of a woman’s transition to menopause. When the eggs stop maturing, ovulation does not occur and menstruation stops, the AMH value will be zero. Therefore, its norm is different for different ages of a woman.
Traditional treatment for ovarian failure
Quite often, we get questions on the blog from women who have taken synthetic hormones for a long time or experienced a lot of stress – “Am I already in premenopause?” At the same time, AMH is already reduced. We feel always very sorry to upset a woman, but the answer is most often yes. But we do not know all the possibilities of our body, premenopause is a loose concept. And if you take care of your health and take care of what is left with trepidation, then you can remain in reproductive age for many more years.
In traditional practice, with a reduced AMH value, a woman is prescribed HRT for life. This is strategically wrong. What saving of the remaining potential of the ovaries can we talk about? On synthetic hormones, the ovaries will “go out” even faster, like all other health.
We saw situations, even with critically low AMH levels, women had regular periods. Children were born with AMH 0.3–0.5 ng/ml. The main thing is that a woman should not “hang” premenopause on herself ahead of time and should not be led to those who intimidate her. Everything is always very individual.
Is it possible to increase the ovarian reserve and prolong the life of the ovaries?
Primordial follicles are one of the only cells in the body that do not regenerate and multiply, it is believed that we can only use them at one rate or another. And our health, quality and life expectancy, as well as the health and reproductive potential of our children depend on it. At least it has been so far. Recent research has sparked promising new insights into egg production—women can actually produce them during their reproductive years. Scientists have discovered stem cells in the ovaries that produce new eggs .
Regardless of this study, age still had an effect on new eggs as the ovaries continued to age, resulting in less than optimal housing for the UC. Protecting the NMCs you currently have, as well as improving ovarian health through lifestyle changes, nutrition, herbs, supplements, bioregulators, and increased circulation to the reproductive system are of paramount importance.
The ovaries are a very resourceful organ. And even with an initially small ovarian reserve, you can slow down the rate of waste of ovarian potential and then you can live for many years, being in a flowering reproductive age.
So, the focus will be on improving egg health, nourishing the endocrine system, and maintaining optimal health of the ovaries, fallopian tubes, and uterus. Below are two schemes, the first is the cellular nutrition of the reproductive organs, the second is their restoration and regeneration.
SCHEME for improving EGG QUALITY and prolonging ovarian life (cellular nutrition)
Who can benefit from the program?
-Women with reduced ovarian reserve,
-having a diagnosis of infertility of any origin, even with normal hormone levels,
-those who wish to improve the quality of the eggs before conception, which will increase the chances of a good health of the embryo (especially in women after 35 years),
-significant improvement in in utero fertilization and IVF protocol, as well as a reduction in the risk of miscarriage after it,
-women who want to delay menopause and improve ovarian function.
For more details please feel free to write us a letter asking your questions or arranging a preliminary free online consultation with Dr. Olena Mozgova in her clinic to issue an individual IVF preparation protocol or start the treatment of your ovaries rejuvenation through uniting efforts with a doctor in your country.